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sulfadoxine 英sʌlfə'dɒksiːn美sʌlfə'dɒksiːn COCA¹⁷⁵⁹⁷⁸ 基本例句 磺胺多辛,周效磺胺 Resistance along the Thai-Cambodia border started with chloroquine, followed by resistance to sulfadoxine-pyrimethamine and mefloquine, drugs used in malaria control several years ago. 泰柬边界地区一开始出现的是对氯喹的耐药性,然后对周效磺胺-乙胺嘧啶以及甲氟喹产生耐药性。 这些药是几年前使用的抗疟药。 who High levels of resistance to chloroquine have forced some countries to switch the first-line drug to sulfadoxine- pyrimethamine. 恶性疟原虫对氯喹的高水平抗性使许多国家把磺胺多辛-乙胺嘧啶作为一线抗疟药。39kf Molecular epidemiological investigations have uncovered the patterns of emergence and global spread of Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine. 分子流行病学调查发现模式的出现和全球传播疟原虫抗氯喹和周效磺胺。 syyxw.com The article reviews the epidemiology, the mechanisms and the factors cause p. f resistance to sulfadoxine-pyrimethamine. 本文综述该复方抗药性流行病学的研究、抗药性产生的机制及促使抗药性产生发展的因素。39kf These findings imply that sulfadoxine-pyrimethamine should be used with utmost caution in early pregnancy as this regimen can lead to folic acid deficiency and consequent pregnancy wastage. 这些结果意味着,周效磺胺应使用极为谨慎早孕,因为这方案可导致叶酸缺乏和随之怀孕浪费。 syyxw.com WHO recommends intermittent preventive treatment with sulfadoxine- pyrimethamine for pregnant women living in high transmission areas, during the second and third trimesters. 世卫组织建议对生活在高传播地区的孕妇使用磺胺多辛—乙胺嘧啶在妊娠中期和晚期进行间歇性预防治疗。 who |