| 释义 |
pinacidil
基本例句
吡那地尔
Abstract:Objective:To investigate the mechanisms ofpinacidilpreconditioning on myocardial protection in hypovolemic shock.摘要：目的：探讨吡那地尔预处理对低血容量性休克大鼠的心脏保护作用机制。Compared with control group,pinacidilpreconditioning group could increase VFT and shorten VVP during ischemia and reperfusion period 在缺血期及再灌注期;与对照组比较吡那地尔0.;2mg/kg预处理组可提高VFT、缩短VVP,pinacidil,acetylcholine , T1~+, and K~+ on early afterdepolarization of mouse atrial fibers were observed.⎩实验观察了lemakalimLem、pinacidilPin、乙酰胆碱Ach、TI＋及高K＋对小鼠心房肌早发后去极化EAD，由低K＋引起的抑制作用。⎫⎤Conclusions:Pinacidil preconditioning can protect myocardial function in hypovolemic shock possibly by stabilizing cell membrane and preventing Ca2+ overload.结论：吡那地尔预处理对低血容量性休克鼠心功能的保护可能与其稳定细胞膜，防止钙超载有关。
Methods:Pinacidil was used 24 hours before the establishment of hypovolemic shock model. The activities of Na +K +ATPase,Ca 2+ ATPase,Mg 2+ ATPase and free Ca 2+ in myocardium were observed at different time points.方法 :预先给予大鼠吡那地尔,2 4小时后复制低血容量性休克模型 ,在不同时间点内观察吡那地尔对心肌钠泵 、钙泵 、Mg2 + ATP酶的活性影响及心肌细胞内游离 Ca2 +的水平变化 ;
Keywords Burns;Myocardium;Mitochondria;Pinacidil;烧伤;心肌;线粒体;吡那地尔; |